Pair map

Amino acids

Fast ionotropic transmitters.

• GlutamateGlu—

  Main fast excitatory (GluN/AMPA/kainate). sharpness; NMDA block → dissociation; excess → seizure risk.

• GABAGABA—

  Main fast inhibitory (GABA-A/B). calm, sedation, amnesia, motor looseness.

• GlycineGly—

  Inhibitory in spinal cord/brainstem; NMDA co-agonist. muscle ease, sleep onset.

• AspartateAsp—

  Excitatory amino acid, NMDA-preferring, less prominent than glutamate. tracks glutamate/NMDA occupancy; rarely isolated subjectively.

Monoamines

Catecholamines, indolamines, histamine.

• DopamineDA—

  Catecholamine — motivation, reward, motor. drive, focus, craving, stereotypy at high occupancy.

• NorepinephrineNE—

  Catecholamine — central alertness. edge, tremor, narrowed attention.

• EpinephrineEpi—

  Catecholamine — adrenal burst. pulse, pallor, fight-or-flight body.

• Serotonin5-HT—

  Indolamine — mood, sensory gain, autonomic. mood lift, empathy, nausea; toxicity if stacked.

• MelatoninMLT—

  Indolamine — SCN night signal. sleep gate; not GABA sedation.

• HistamineHA—

  Monoamine — tuberomammillary wake. sedation if blocked; itch if raised.

Acetylcholine

Its own class. Not a monoamine.

• AcetylcholineACh—

  Cholinergic — attention, memory, parasympathetic. focus vs anticholinergic fog, dry mouth.

Neuropeptides

Often co-released with classical transmitters.

• Opioid peptidesOp—

  Endorphins / enkephalins / dynorphins. analgesia, euphoria, constipation, respiratory depression.

• Substance PSP—

  Tachykinin — nociception, inflammation. pain gain; opioid systems often suppress it.

• Neuropeptide YNPY—

  Feeding, stress, vascular tone. appetite / anxiolysis at some sites; rarely isolated in this log.

• OxytocinOXT—

  Social salience, bonding. openness, trust; not a universal 'love' switch.

• VasopressinAVP—

  Water balance, social, vascular. ethanol suppresses ADH → diuresis; high AVP → vasoconstriction.

• CCKCCK—

  Satiety, GI, panic-circuit peptide. fullness; CCK-B can provoke anxiety in experiments.

• SomatostatinSST—

  Inhibitory peptide, GH and many CNS circuits. rarely a distinct felt state in this library.

• OrexinOrx—

  LH peptide — stabilized wakefulness. holding wake; low orexin → sleep attacks.

Purines

ATP and its metabolite adenosine.

• ATPATP—

  Purine transmitter / gliotransmitter. not felt as ATP; rapidly becomes adenosine.

• AdenosineAdo—

  Purine — sleep pressure, A1/A2A. wakefulness if blocked; rebound fatigue.

Gasotransmitters

Membrane-permeant retrograde messengers.

• Nitric oxideNO—

  Gas — nNOS, retrograde, vascular. no isolated 'NO high'; NMDA-linked and vasodilatory.

• Carbon monoxideCO—

  Gas — heme oxygenase, neuromodulation. not a recreational signal; endogenous only here.

• Hydrogen sulfideH₂S—

  Gas — cysteine metabolism, cytoprotection. not a distinct acute feel; NAC-adjacent biochemistry.

Endocannabinoids

On-demand retrograde lipids at CB1/CB2.

• AnandamideAEA—

  eCB — AEA at CB1/CB2/TRPV1, FAAH-cleared. quieter retrograde brake; CBD can raise AEA via FAAH.

• 2-AG2-AG—

  eCB — 2-AG, main CB1 endocannabinoid, MAGL-cleared. primary on-demand CB1 tone; THC occupies the same receptors.

Also tracked

Not classical transmitters; still in the occupancy model.

• Cortisol / HPA—
• Ion channels—